別    名 fatty acid synthase;FAS; FASN; FA Synthase 1; MGC14367; MGC15706; OA-519; Fatty acid synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; Enoyl-[acyl-carrier-protein] reductase; Oleoyl-[acyl-carrier-protein] hydrolase; FAS_HUMAN.  

 研究領域 腫瘤  心血管  免疫學  神經(jīng)生物學  信號轉(zhuǎn)導  激酶和磷酸酶  合成與降解  

 抗體來源 Rabbit

 克隆類型 Monoclonal

 克 隆 號 9B6

 交叉反應 (predicted: Human, Mouse, Rat, )

 產(chǎn)品應用 WB=1:1000 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:50-200 IHC-F=1:450-200 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

 分 子 量 273kDa

 細胞定位 細胞漿 

 性    狀 Liquid

 濃    度 1mg/ml

 免 疫 原 Recombinant human Fatty Acid Synthase: 

 亞    型 IgG

 純化方法 affinity purified by Protein A

 儲 存 液 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

 保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

 PubMed PubMed

 產(chǎn)品介紹 FASN (Fatty Acid Synthase) is a central enzyme in de novo lipogenesis. FAS is a target for SREBP and is upregulated by LXR activation; it is also one of the accepted markers for insulin resistance, SREBP and LXR activation.

 

Function:

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

 

Subunit:

Homodimer which is arranged in a head to tail fashion.

 

Subcellular Location:

Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

 

Tissue Specificity:

Ubiquitous. Prominent expre

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