別    名 signal transducers and activators of transduction2; Homo sapiens interferon alpha induced transcriptional activator; interferon alpha induced transcriptional activator; ISGF3; P113; signal transducer and activator of transcription 2 113kD; STAT113; STAT2_HUMAN; p113.   

 研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  

 抗體來源 Rabbit

 克隆類型 Monoclonal

 克 隆 號 4B1

 交叉反應(yīng) (predicted: Human, )

 產(chǎn)品應(yīng)用 WB=1:500-1000 IHC-P=1:50-200 IHC-F=1:400-800 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

 分 子 量 97kDa

 細(xì)胞定位 細(xì)胞核 細(xì)胞漿 

 性    狀 Liquid

 濃    度 1mg/ml

 免 疫 原 Recombinant human STAT2 protein (1-100aa): 

 亞    型 IgG

 純化方法 affinity purified by Protein A

 儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

 保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

 PubMed PubMed

 產(chǎn)品介紹 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

 

Function:

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 an

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