研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞骨架   

抗體來源 Rabbit 

克隆類型 Monoclonal 

克 隆 號(hào) 3B7 

交叉反應(yīng) (predicted: Human, Mouse, Rat, ) 

產(chǎn)品應(yīng)用 WB=1:1000-2000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user. 

分 子 量 50kDa 

細(xì)胞定位 細(xì)胞漿  

性    狀 Liquid 

濃    度 1mg/ml 

免 疫 原 KLH conjugated synthetic peptide derived from human Tubulin beta-III:  

亞    型 IgG 

純化方法 affinity purified by Protein A 

儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 

保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 

PubMed PubMed 

產(chǎn)品介紹 Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance.

 

Function:

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance.

 

Subcellular Location:

Cytoplasm, cytoskeleton.

 

Tissue Specificity:

Expression is primarily restricted to central and peripheral nervous system.

 

Post-translational modifications:

Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, c

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