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                                                              PF 4 Human
                                                              英文名稱:PF 4 Human總訪問:222
                                                              國產(chǎn)/進(jìn)口:進(jìn)口半年訪問:3
                                                              產(chǎn)地/品牌:prospec產(chǎn)品類別:細(xì)胞生物學(xué)試劑
                                                              規(guī)       格:CHM-234 最后更新:2024-12-5
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                                                              Catalogue Number CHM-234
                                                              Synonyms CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.
                                                              Introduction Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
                                                              Description Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues.
                                                              Source Human Platelets.
                                                              Physical Appearance Sterile Filtered white lyophilized powder.
                                                              Formulation The CXCL4 protein was lyophilized in PBS buffer pH-7.4.
                                                              Solubility It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
                                                              Stability Human CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C.
                                                              Please prevent freeze-thaw cycles.
                                                              Purity Greater than 95.0% as determined by(a) Analysis by RP-HPLC.
                                                              (b) Analysis by SDS-PAGE.
                                                              Amino acid sequence The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu.
                                                              Activity Control Binding of HIT-antibodies.
                                                              Usage ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY.They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.
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