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                                                              當(dāng)前位置 > 產(chǎn)品目錄 > 試劑 > 細(xì)胞生物學(xué)試劑 > IP 10 Rat
                                                              



                                                              

                                                              
 
	
                                                              

		
                                                              
			
                                                              
			  
                                                              
			    
				
				IP 10 Rat
					
			    
				
					
					
                                                              
						
                                                              
							英文名稱：IP 10 Rat總訪問：180		
						
                                                              
						
                                                              
							國產(chǎn)/進(jìn)口：進(jìn)口半年訪問：1 
						
                                                              
						
                                                              
							產(chǎn)地/品牌：prospec產(chǎn)品類別：細(xì)胞生物學(xué)試劑
						
                                                              
						
                                                              
							規(guī)       格：CHM-264

	
	最后更新：2024-12-5
						
                                                              
						
                                                              
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Catalogue Number 
CHM-264 
                                                              

                                                              
Synonyms 


                                                              C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, Gamma-IP10, IP-10, Interferon-inducible protein 10, Protein Mob-1, Small-inducible cytokine B10, Cxcl10, Inp10, Mob1, Scyb10. 
                                                              

                                                              
Introduction 
Chemokine (C-X-C motif) ligand 10 (CXCL10) is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-gamma-induced protein (?-IP10 or IP-10). CXCL10 is secreted by several cell types in response to IFN-?. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes and T cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A. 
                                                              

                                                              
Description 


                                                              IP-10 Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8.6kDa.
                                                              The IP-10 is purified by proprietary chromatographic techniques.
                                                              

                                                              
Source 
Escherichia Coli. 
                                                              

                                                              
Physical Appearance 
Sterile Filtered White lyophilized (freeze-dried) powder. 
                                                              

                                                              
Formulation 
Lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4. 
                                                              

                                                              
Solubility 
It is recommended to reconstitute the lyophilized IP-10 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. 
                                                              

                                                              
Stability 
Lyophilized IP-10 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL10 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
                                                              Please prevent freeze-thaw cycles. 
                                                              

                                                              
Purity 
Greater than 97.0% as determined by:
                                                              (a) Analysis by RP-HPLC.
                                                              (b) Analysis by SDS-PAGE. 
                                                              

                                                              
Amino acid sequence 


                                                              IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP.
                                                              

                                                              
Biological Activity 


                                                              Determined by its ability to chemoattract hCXCR3/HEK293 cells using a concentration range of 10.0-50.0 ng/ml.
                                                              

                                                              
Usage 
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. 
                                                              >
                                                              bio-equip.com
                                                              

			
                                                              
			
					  
		
                                                              
		
	
                                                              

                                                              

 


                                                              
	
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