別    名 IPO B; Manganese SOD; Superoxide Dismutase 2; Manganese superoxide dismutase; Mn SOD; MNSOD; SOD 2; SOD-2; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn] mitochondrial precursor; Superoxide dismutase 2 mitochondrial; SODM_HUMAN.   

研究領(lǐng)域 神經(jīng)生物學(xué)  細(xì)胞凋亡  激酶和磷酸酶  線粒體   

抗體來源 Rabbit 

克隆類型 Monoclonal 

克 隆 號 3G5 

交叉反應(yīng) (predicted: Human, Mouse, Rat, ) 

產(chǎn)品應(yīng)用 WB=1:1000-2000 IHC-P=1:50-200 IHC-F=1:50-200 （石蠟切片需做抗原修復(fù)）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user. 

分 子 量 22kDa 

細(xì)胞定位 細(xì)胞漿 線粒體 

性    狀 Liquid 

濃    度 1mg/ml 

免 疫 原 KLH conjugated synthetic peptide derived from human SOD2:  

亞    型 IgG 

純化方法 affinity purified by Protein A 

儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 

保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 

PubMed PubMed 

產(chǎn)品介紹 This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

 

Function:

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

 

Subunit:

Homotetramer.

 

Subcellular Location:

Mitochondrion matrix.

 

Post-translational modifications:

Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.

Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting.

 

DISEASE:

Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pa

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