別    名 Major synaptic vesicle protein P38; MRXSYP; Syn p38; Synaptophysin; SYP; SYPH; SYPH_HUMAN; SypI.   

研究領域 細胞生物  神經(jīng)生物學   

抗體來源 Rabbit 

克隆類型 Monoclonal 

克 隆 號 2B1 

交叉反應 (predicted: Human, Mouse, Rat, ) 

產(chǎn)品應用 WB=1:1000-5000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user. 

分 子 量 34kDa 

細胞定位 細胞漿  

性    狀 Liquid 

濃    度 1mg/ml 

免 疫 原 KLH conjugated synthetic peptide derived from human Synaptophysin:  

亞    型 IgG 

純化方法 affinity purified by Protein A 

儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 

保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 

PubMed PubMed 

產(chǎn)品介紹 This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011]

 

Function:

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.

 

Subcellular Location:

Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome.

 

Tissue Specificity:

Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.

 

Post-translational modifications:

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.

 

DISEASE:

Defects in SYP are the cause of mental retardation X-linked SYP-related (MRXSYP) [MIM:300802]. Mental retardation is characterized by significantly below average general intellectu

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