A Ca(2+) sensitizer that increases contractile force of the myocardium by enhancing the sensitivity of
myofilaments to calcium without increasing intracellular calcium concentration. It has been shown
to reduce circulating proinflammatory cytokine interleukin-6 and soluble apoptosis mediators.




Specifications







Cas No.
141505-33-1



Product ID
L1884



Product Name
Levosimendan




Chemical Name
Mesoxalonitrile (-)-(p((R)-1,4,5,6-tetrahydro-4-methyl-6-
oxo-3-pyridazinyl)phenyl)hydrazone



Synonym
Simdax



Formula Wt.
280.28



Melting Point
210^oC-214^oC



Purity
≥98%




Solubility
Soluble in water.



Stability
Store in a cool, dry place. Protect from direct light.



Store Temp
+4^oC



References
Udvary E, Papp JG, Vegh A. Br J Pharmacol. 114:656-61 (1995).
Parissis JT, Adamopoulos S, Antoniades C et al. Am J Cardiol. 93:1309-12 (2004).
Eriksson O, Pollesello P, Haikala H. J Cardiovasc Pharmacol. 44:316-21 (2004).